The search for therapeutic strategies for the treatment of psoriasis is a challenge in the field of dermatology. Regenerative medicine has offered encouraging alternatives to patients with few therapeutic options. An investigation to assess the application of autologous platelet-rich plasma in patients diagnosed with psoriasis, using a quasi-experimental study, in the period between September 2014 and February 2016, the consultation of Dermatology was performed at Military Hospital “Comandante Manuel Fajardo” of Santa Clara city, and evaluated in the multidisciplinary consultation regenerative therapy at Biomedical Research Unit of the University of Medical Sciences of Villa Clara. Nine patients, whom met the criteria designed for this purpose are included. Autologous platelet-rich plasma was applied perilesional every 21 days, periodically each lesion was evaluated. Behind the second application the injuries diminished of size in 66.6 % of the patients, to the fourth treatment in the 77.7 % the injuries had attenuated intensely. Behind the fifth application five patients were asymptomatic. The perilesional application of platelet-rich plasma was effective in the treatment of psoriasis.